What did Pacific Edge Limited announce?

Pacific Edge Limited (NZX: PEB) filed “Pacific Edge 2026 Annual Shareholders Meeting” with NZX on 20 August 2026, as an agm announcement.

When was it filed?
20 August 2026
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NZX announcement
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Pacific Edge 2026 Annual Shareholders Meeting

AGM20 August 2026PEBHealthcare

20 August 2026
PACIFIC EDGE 2026 ANNUAL SHAREHOLDERS MEETING

DUNEDIN, New Zealand – Cancer diagnostics company Pacific Edge (NZX, ASX: PEB) is

holding its Annual Shareholder Meeting in Auckland this afternoon.

It attaches Chairman Simon Flood’s speech notes and the company’s presentation to

shareholders.

Released for and on behalf of Pacific Edge by Grant Gibson Chief Financial Officer.

Investors: Media:

Dr Peter Meintjes Richard Inder

Chief Executive The Project

Pacific Edge P: +64 21 645 643

P: +64 22 032 1263

OVERVIEW

Pacific Edge: www.pacificedgedx.com

Pacific Edge Limited (NZX/ ASX: PEB) is a global cancer diagnostics company leading the way

in the development and commercialization of bladder cancer diagnostic and prognostic tests

for patients presenting with hematuria or surveillance of recurrent disease. Headquartered in

Dunedin, New Zealand, the company provides its suite of Cxbladder tests globally through its

wholly owned, and CLIA certified, laboratories in New Zealand and the USA.

Cxbladder: www.cxbladder.com

Cxbladder is a suite of non-invasive genomic urine tests optimized for the risk stratification of

urothelial cancer in patients presenting with hematuria and those being monitored for recurrent

disease. The tests help improve the overall patient experience, while prioritizing time and

clinical resources to optimize practice workflow and improve efficiency.

Supported by over 20 years of research, Cxbladder’s evidence portfolio extends to more than

twenty-five peer reviewed publications, and Cxbladder Triage is now included in the American

Urological Association’s Microhematuria Guideline. To drive increased adoption and improved

patient health outcomes, Cxbladder is the focal point of numerous ongoing and planned studies

designed to generate further clinical utility evidence.

Cxbladder is available in the US, Australasia, and Israel and in markets throughout Asia and

South America. In the US, the test has been used by over 5,000 urologists who have ordered

more than 130,000 tests. In New Zealand, Cxbladder is accessible to around 70% of the

population via public healthcare and all residents have the option of buying the test online.

---

2026 ANNUAL SHAREHOLDERS’
MEETING PRESENTATION

Simon Flood

Chairman

Dr Peter Meintjes

Chief Executive Officer

20 August 2026

1

2
SIMON FLOOD

Chairman

CHAIRMAN’S ADDRESS

This presentation has been prepared by Pacific Edge Limited (PEL) to
provide PEL shareholders with information about PEL and its activities at

PEL’s 2026 Annual Shareholders’ Meeting (ASM).

A reference in this Important Notice and Disclaimer to the Information

means the information in this presentation, any written address released

to NZX and ASX in respect of this presentation, and any verbal remarks

made by PEL directors or management at the ASM (including answers to

shareholder questions) in respect of the matters addressed in this

presentation.

Unless otherwise specified, the Information is stated at the date of this

presentation.The Information should be read in conjunction with PEL’s

Annual Report, half-year financial statements, and continuous disclosure

announcements released to NZX and ASX at

•www.nzx.com/companies/PEB; and

•https://www.asx.com.au/markets/company/PEB

Information of a general nature

The Information is of a general nature only and does not purport to be

complete or comprehensive. It does not contain all the information that

a person may require in evaluating or making an investment decision in

respect of PEL shares. Nor does it take into account any person’s

objectives or circumstances.

Not an offer

The Information is for informational purposes only. It is not an invitation

or offer of securities for subscription, purchase or sale for any purpose

or in any jurisdiction.

Not financial product advice

The Information does not constitute legal, financial, tax, investment, or

financial product advice, and is not a recommendation to invest in or

deal with PEL shares.

Past performance, including past PEL share price performance, cannot be

relied on as an indicator of future performance, including in respect of

PEL’s future financial performance, PEL’s future financial position, or

future PEL share price performance. Any investment in PEL shares is

subject to various risks, including those set out on pages 26 to 28 of

PEL’s Capital Raising Presentation that was released by NZX and ASX on

11 May 2026. If you are considering investing in or dealing with PEL

shares, you are encouraged to read those risks carefully, and to seek

your own professional advice, before you do so.

Forward-looking statements

The Information contains forward-looking statements that relate to

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Non-GAAP financial information

The Information contains certain financial measures that are “non-GAAP

financial information” under the New Zealand Financial Markets

Authority Guidance Note on disclosing non-GAAP financial information

and “non-IFRS financial information” under the ASIC Regulatory Guide on

disclosing non-IFRS financial information (and potentially under other

regulatory guidelines or rules).

Such financial information and financial measures (including Cash Burn)

do not have standardized meanings prescribed under NZ IFRS or IFRS and

therefore, may not be comparable to similarly titled measures presented

by other entities, and should not be construed as an alternative to other

financial measures determined in accordance with NZ IFRS, or IFRS).

Currency

All dollar values to in the Information are in New Zealand dollars unless

otherwise stated.

Effect of rounding

A number of figures, amounts, percentages, estimates, calculations of

value and fractions in the Information are subject to the effect of

rounding. Accordingly, the actual calculations may differ.

Disclaimer

PEL has sought to use reasonable care to prepare the Information.

However, PEL and its related bodies corporate and affiliates, and their

respective directors, officers, partners, employees, agents, associates

and advisers (each such person, a PEL Person) do not make or provide

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nature in respect of the Information (including, without limitation, as to

the accuracy, reliability or completeness of any of the Information or as

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No PEL Person is required or under any obligation to update this

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Rules, no PEL Person is required or under any obligation to update the

Information.

To the maximum extent permitted by law, each PEL Person disclaims,

and no PEL Person shall have any, liability of any nature (including,

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in connection with (1) any person’s reliance on or use of the Information;

(2) any errors in or omissions from the Information; or (3) any failure to

update or correct the Information.

IMPORTANT NOTICE AND DISCLAIMER

3

DIRECTORS
4

SARAH PARK

ANNA STOVETONY BARCLAY

BRYAN WILLIAMS

ANATOLE MASFEN

1.CHAIRMAN’S ADDRESS
2.CHIEF EXECUTIVE’S ADDRESS

3.QUESTIONS

4.RESOLUTIONS

5.VOTING AND GENERAL BUSINESS

6.MEETING CLOSE

AGENDA

5

PACIFIC EDGE - THE FIRST MOVER IN BLADDER CANCER DIAGNOSTICS
MAJOR GROWTH CATALYST: DRAFT MEDICARE COVERAGE PROPOSED IN MAY 2026

SCIENCE, TECH AND IPCLINICAL EVIDENCE

SUBSTANTIAL MARKET

OPPORTUNITY

GROWTH CATALYST WITH

MEDICARE COVERAGE

Cxbladder tests are patented

non-invasive urine tests that

deliver proven clinical,

economic and patient value

Cxbladder tests are supported by a

robust portfolio of clinical evidence,

and the AUA

1

has recognized Cxbladder

Triage with a ‘Grade A’ evidence rating

– the only urine biomarker to achieve

that rating

The primary symptom of bladder

cancer is hematuria with ~7m

diagnoses each year in the US driving

a global market opportunity of

US$10.2 billion

Draft LCD

2

for Triage & Triage

Plus released in May 2026. Final

LCD expected by Jan 2027

3

.

Novitas confirms claim-by-claim

reimbursement for both tests

6

1.AUA = American Urological Association,

2.LCD = Local Coverage Determination.

3.Novitas must publish the final LCD or retire the draft LCD within 365 days after publishing a draft LCD

4.See slides 44-46 for assumptions

US$10.2b

4

Global Market Opportunity

Jan 2026
Kaiser RWE published

supporting Triage.

Largest ever UBB

1


hematuria study

Feb 2026

CAC Panel expresses

clear support for

UBBs in hematuria

evaluation

May 2026

Novitas publishes

DL40378 with

coverage for Triage

Plus and Triage

Dec 2014

Launch of

Cxbladder

Triage

Nov 2023

Kaiser EMR

integration

goes live

Dec 2022

Lotan et al:

Enhanced

Cxbladder

Tests Deliver

Improved

Performance.

Journal of

Urology

Feb 2018

Cxb Triage

adopted into

Canterbury

Community Health

Pathways with

primary care

referral

2011

2011

Pacific Edge

Diagnostics

New Zealand

(PEDNZ)

established

2012

Dec 2012

Launch of Pacific Edge

Diagnostics USAand

Cxb Detect

2013

Mar 2013

First commercial

sale (Cxb Detect)

for PEDUSA

May 2013

First commercial

sale (Cxb Detect)

for PEDNZ

2014

2015

Dec 2015

Launch of

Cxbladder

Monitor

2016

2018

2019

2020

Jun 2020

Kaiser Permanente,

approves commercial

use of Cxbladder

Jul 2020

Medicare

reimbursement of

Cxbladderat

US$760/test

2021

Aug 2021

Cxbladder reaches

70% public

healthcare

coverage in NZ

2022

2023

2024

May 2024

STRATA podium

presentation at

AUA 2024.

Study published

in Journal of

Urology

Timeline: Company Milestones

2025

Feb 2025

Triage included in AUA

Microhematuria

Guideline

Apr 2025

Medicare non-

coverage

effective

Nov 2025

Triage Plus gets CMS

draft price of

US$1,328

2026

1.UBBs are urine-based biomarkers – a term adopted by AUA in their guidelines

FY26: A YEAR OF STRATEGIC DELIVERY
ADVANCING MEDICARE COVERAGE GOALS; COSTS CONTAINED

8

$2.4M

2H 26CASH

BURN/MONTH

DOWN 27.7% ON

1H 26

-$35.8M

NET LOSSAFTER

TAX UP 19.5%

on FY25

$2.4M

2H 26CASH

BURN/MONTH

DOWN 27.7% ON

1H 26

STRATEGIC HIGHLIGHTS

•February 2026, CAC Panel expresses clear support for UBBs in hematuria evaluation

•May 2026, Novitas publishes draft LCD ‘Urine-based Biomarkers in Patients with

Microhematuria’ (DL40378) supporting coverage of Cxbladder Triage and Triage Plus

•Expect final effective Medicare coverage by the end of 2026.

•Building US commercial payer momentum, with medical policy for hematuria

evaluation tests from insurers covering 10.5 million lives.

•Asia Pacific operations advance towards profitability on a direct cost basis

FINANCIAL HIGHLIGHTS

•FY26 operating revenue fell due to Medicare non-coverage determination; APAC

shows steady growth on smaller volumes

•2H 26 cash burn reduced through careful expense management; targeting a monthly

average cash burn for FY27 of NZ$2.5m vs NZ$2.85m for FY26.

•A post balance date $36.1 million capital raising to strengthen our balance sheet and

drive revenue growth

18,783

COMMERCIAL

TESTS -23.8%

on FY25

$11.5M

OPERATING

REVENUE

-47.4% on

FY25

9
DR PETER MEINTJES

Chief Executive Officer

CHIEF EXECUTIVE’S ADDRESS

VALUE CREATION THROUGH THREE PILLARS
OUR PEOPLE

OUR PROCESSES

OUR IP, KNOWLEDGE

AND EXPERIENCE

OUR CLINICAL STUDIES

PARTNER SITES

OUR INVESTORS

EARLY DETECTION AND

CLINICALLY ACTIONABLE CARE

INNOVATION PIPELINE FOR

CLINICAL APPLICATIONS

INCLUSIVE WORKPLACE

DRIVEN BY OUTCOMES

INCREASED LONG-TERM

SHAREHOLDER VALUE

EXCELLENT PATIENT EXPERIENCE

AND ACCURATE RESULTS

INPUTSOUTPUTS

A VALUES DRIVEN, DIVERSE, RESULTS-FOCUSED CULTURE

SCALABLE PROCESSES, TRAINING & QUALITY SYSTEMS,CONTINUOUS IMPROVEMENT

DIGITALIZED ARCHITECTURE, AUTOMATED OPERATIONS, REAL-TIME ANALYSIS

10

PACIFIC EDGE: LEADER IN URINE-BASED BIOMARKER TESTING
STRONG EXECUTION ON EVIDENCE-PILLAR UNDERPINS FUTURE COMMERCIAL SUCCESS

11

•Draft LCD supporting Medicare coverage of Cxbladder Triage & Triage Plus; Final and

effective LCD expected by end of 2026

•Rigorous clinical evidence program to extend risk thresholds in guidelines/medical

policy to deliver a larger serviceable market

•US Commercial testing stabilizes; set to rise with final coverage

•Medical policy wins with US commercial payers increasing; over 10.5 million lives

now covered with commercial policy for Cxbladder Triage

•Advancing APAC towards profitable operations on a direct cost basis

•Driving long-term enterprise value with product improvements and new products

•Triage Plus at $1,328 and Surveillance Plus at $1,800

1

create higher margin

opportunity and improved unit economics

1.Management estimate of US$1,800 for NMIBC surveillance is based on proposed crosswalk and is not yet priced by Medicare

NOVITAS PROPOSED DRAFT COVERAGE FOR TRIAGE AND TRIAGE PLUS
12

“Use of validated multi-analyte UBBs may be

reasonable and necessary to support risk-

stratification in appropriately counseled,

intermediate-risk patients with MH who are

considering deferral of cystoscopy.”

- DRAFT LCD: ‘Urine-based Biomarkers in Patients

with Microhematuria’ (DL40378)

FINALIZED LCD EXPECTED TO ACCLERATE PACIFIC EDGE’S PATH TO PROFITABILITY

•Triage and Triage Plus proposed for Medicare coverage

•No other biomarkers proposed for Medicare coverage

•Final effective coverage expected before the end of the year

•Final LCD expected to catalyze reimbursement and testing volume

•Our immediate commercial focus is to:

•Improve the unit economics of operating front line sales team

•Shift our customer base to order Triage Plus ($1,328) on every eligible

patient

•Ensuring payment success of >80% on commercial tests by operating

where we have reliable history of commercial success or existing medical

policy and contracting

US$10.2b
Global TAM

1

CXBLADDER MARKET OPPORTUNITY

CXBLADDER OFFERS A SIGNIFICANT ADDRESSABLE GLOBAL MARKET ANNUALLY

~17m0.47m | 2.71m | 3.46m1.7m ~58k ~300k US$1.9b830m

~12m0.34m | 1.96m | 2.5m1.7m ~180k ~1mUS$1.9b600m

APAC

Primary growth

focus due to higher

CMS pricing

NZ market mature.

Australia and SEA in

business development

New market accessed

via IVD / kitted tests

1.Pacific Edge estimate using US$1,328 price for hematuria testing (priced by Medicare) in the US and US$1,800 for NMIBC surveillance (seeking crosswalk price – not yet priced by

Medicare) with next generation products Triage Plus and Surveillance Plus. Other market assumptions for APAC and Europe. See slide 44-46 for details.

2.RDM: Residual Disease Monitoring

3.TRM: Therapeutic Response Monitoring

4.Management estimates derived from referred hematuria data in Woldu et al (2021). MH estimated at 80% and GH at 20%. MH Risk categories: Low 7%, Intermediate 41%, High 52%. See

Slide 44-46 for details.

All

hematuria

Microhematuria

4

Low | Intermediate | High

Gross

4


Hematuria

Annual cases of

bladder cancer

Living with bladder cancerTAMPopulation

SURVEILLANCE

(RDM

2

, TRM

3

, RECURRENCE)

PATIENT/DISEASE MANAGEMENT

(CLINICAL DECISION MAKING)

13

~7m0.20m | 1.14m | 1.46m0.7m ~90k ~750k US$6.4b340m

14
AUA 2027 HEMATURIA GUIDELINE REVIEW IN FOCUS

•STRATA second publication

•Simplify Triage utility messaging; will include the

clinical outcomes of imaging

•AUSSIE and microDRIVE

•Clinical validation of Triage Plus

•MH & GH Pooled Analyses

•Demonstrate concordance between Triage and Triage

Plus

•Demonstrate equivalent performance in all MH risk

categories and GH

•Analyze across age, gender and ethnicity

Collectively, these studies are expected to re-define

the AUA risk stratification thresholds for greater

serviceable market

DRIVING CLINICAL VALUE FOR PHYSICIANS, HOSPITALS AND PAYERS

COMPELLING CLINICAL EVIDENCE CHANGES CLINICAL PRACTICE, MEDICAL POLICY AND GUIDELINES

1.Clinical Utility (CU) - Evidence a test that can usefully change patient management within the context of care for the defined population and indication Clinical Validity (CV) - Evidence a test

works in the same way on an independent eligible population for a given indication. Analytical validity (AV) - Evidence a test is repeatable in the lab for a given indication and population

STUDY

TEST AND EVIDENCE

PUBLICATION DATE

(1)

1. STRATA Clinical Utility

- CU of Triage

Published May 2024

2. Automated RNA & DNA extraction

- AV of Triage, Detect and Monitor

Published September 2024

3. Triage Plus Analytical Validation

- AV of Triage Plus

Published July 2025

4. DRIVE Clinical Validation

- CV of Triage Plus

Published October 2025

5. STRATA second publication

- CU of Triage

Q3 2027

6. AUSSIE Clinical Validation

- CVof Triage Plus

Q3 2026 (+1Q)

7. microDRIVE Clinical Validation

- CV of Triage Plus

Q1 2027 (+1Q)

8. Surveillance Plus Analytical Validation

- AV of Surveillance Plus

Q2 2027 (+3Q)

9. Pooled Analysis MH Clinical Validation

2

- CV of Triage Plus

Q2 2027 (+1Q)

10. Pooled Analysis GH Clinical Validation

2

- CV of Triage Plus

Q2 2027 (+1Q)

11. LOBSTER Clinical Validation

- CV of Monitor/Surveillance Plus

Q3 2027 (+3Q)

12. CREDIBLE Clinical Utility

- CU of Triage Plus

Q1 2028 (at risk)

13. OCTOPUS Clinical Utility

- CU Surveillance Plus

No timeline at this point

1

All dates are calendar year and our best current estimates

2

The MH and GH pooled analysis brings together data from DRIVE, AUSSIE and microDRIVE

Already published evidence

Expected to be published before AUA microhematuria guideline committee initiates next literature review in Q3 2027

INDEPENDENT STUDIES SUPPLEMENT OUR EVIDENCE PORTFOLIO
HIGH IMPACT RESEARCH AT LOW COST

1.All dates are calendar year and our best current estimates

2.Filson et al (2026); Real-World Utility of Cxbladder Triage for Patients with Microhematuria: A Matched Cohort Study, Urology Practice® (2026), doi:

10.1097/UPJ.0000000000000972.

3.BCG: Bacillus Calmette–Guérin is a bacterium instilled into the bladder that triggers an immune response that targets and destroys cancer cells.

4.MIBC: Muscle Invasive Bladder Cancer

INDEPENDENT STUDY FOCUSINSTITUTIONTEST AND EVIDENCE TYPE

PUBLICATION

DATE

1

Real World Utility of Triage in MH: A Matched

Cohort Study

Kaiser Permanente, USCU Triage (RWE)Q1 2026

2

Patient preference and satisfaction of

“biomarkers vs cystoscopy”

Mayo Clinic, USCU MonitorQ3 2026

NZ Hematuria Pathway comparing T/D with

Triage Plus on AUSSIE samples

Canterbury DHBCU of Triage PlusQ3 2026

Retrospective concordance of Triage and Triage

Plus in the Kaiser System

Kaiser Permanente, USCU Triage Plus2027

Test utility in screening patients at risk for

bladder cancer

UT Southwestern, USCU Triage Plus 2027

Test utility in assessing therapy success in a

reduced chemotherapy protocol for upper tract

tumors

Israel Institute of

Technology, Israel

CU Monitor

CU Surveillance Plus

2027

Test utility in assessing response to BCG

3

in high-

grade bladder cancer patients

University of Miami, US

CU Monitor

CU Surveillance Plus

2027

Test utility for the surveillance of MIBC

4

treated

with bladder sparing methods (PRESERVE Trial)

Cleveland Clinic, US

CU Monitor

CU Surveillance Plus

2028

A Randomized Trial of Apalutamide in Non-

Muscle Invasive Bladder Cancer

National Institutes of

Health, US

CU Monitor

CU Surveillance Plus

2029

Already published evidence

15

•Investigator initiated trials (IITs) are

independent studies in which Pacific Edge

typically provides free testing, so provide

significant value at low cost

•IITs extend the evidence portfolio for new

indications of existing tests and may inform

new ‘core’ clinical trials

•IITs are an important part of Key Opinion

Leader (KOL) engagement and generate

publications or podium presentations that

give profile to Cxbladder and Pacific Edge

COMMERCIAL TESTS STABILIZED; SET TO RISE WITH FINAL COVERAGE
16

COMMERCIAL AND TOTAL THROUGHPUT STABILIZED

•Commercial and total throughput stable over

last three quarters

•Sales efficiency improved as sales FTE lowered

to address cash burn

•Seeking to shift commercial product mix to

Triage Plus for higher margins

US TOTAL TEST VOLUME

1

AND COMMERCIAL PRODUCT MIX

1.Total Laboratory Throughput including commercial, pre-commercial and clinical studies testing

2.Pacific Edge has previously used Total Lab Throughput, but has changed its reporting to focus on Commercial throughput, which accounts for the differences in reported figures compared to previous quarterly and half yearly reporting

23%

62%

85%

85%

87%

86%

58%

23%

1%

1%

2%

1%

1%

18%

14%

14%

13%

13%

13%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Q4 25Q1 26Q2 26Q3 26Q4 26Q1 27

PRODUCT MIX (%)

TriageDetectTriage PlusMonitor

5,295

4,600

3,786

3,010

3,375

3,295

1,195

1,122

1,187

1,015

689

540

6,490

5,722

4,973

4,025

4,064

3,835

-

1,000

2,000

3,000

4,000

5,000

6,000

7,000

8,000

Q4 25Q1 26Q2 26Q3 26Q4 26Q1 27

TEST VOLUME

Clinical and non-commercial tests Commercial Volume

COMMERCIAL STRATEGY WITH DRAFT MEDICARE COVERAGE
CONFIGURING OUR SALES TEAM AROUND INTERMEDIATE RISK PATIENTS

•Pacific Edge’s near-term success relies on reducing our cash burn:

•Identify call points with high numbers of intermediate risk microhematuria (IRMH)

patients

•Migrate customers to Triage Plus

•Targeting intermediate risk microhematuria (IRMH) patients

•Women’s health providers are a major opportunity, because IRMH patients are

predominantly female

•IRMH patients are commonly seen by URPS, urogyns, OBGYN and FPMRS

1

•Systems integrated between primary care and secondary care are another major

opportunity

•Urologists frequently triage IRMH patients with APPs, NPs and PAs

2


•Commercial sales teams focused concentrations of demand:

•Integrated Delivery Networks

•Hospital Systems, Academic Institutions, Veterans Association

•Pacific Edge is making selective investments aimed at growing Triage Plus

volume ordered on IRMH patients that have the highest chance of

reimbursement success and delivering consistent revenue

17

1.URPS is Urogynaecology and Reconstructive Pelvic Surgery, urogyn is urogynaecologist, OBGYN is Obstetrician-Gynaecologist and FPMRS is Female Pelvic Medicine and Reconstructive Surgery

2.Advanced Practice Providers (APPs), Nurse Practitioners (NPs) and Physicians Assistants (PAs)

3.Management estimates derived from referred hematuria data in Woldu et al (2021)


PATIENT FEMALE MALE

Low risk 80%20%

Intermediate risk 75%25%

High risk 34%66%

SEX ASSIGNED AT BIRTH FOR HEMATURIA PATIENTS

3

HEALTHCARE PROVIDER TYPE
(SHARE OF PATIENT VOLUME)

3

INTEGRATED DELIVERY NETWORKS

(SHARE OF PATIENT VOLUME)

3

PRIVATE PRACTICE

(SHARE OF PATIENT VOLUME)

3

1.14m

US annual population of

‘intermediate risk’

hematuria evaluation

patients

60%

40%

IDNsPrivate Practice

80%

20%

Large Urology Group

Practices

Community Urology

51%

30%

8%

7%

4%

Hospital Networks

Academic Centers

Veterans Administration

Kaiser Permanente

Other

INTERMEDIATE RISK MICROHEMATURIA SALES APPROACH

INTEGRATED DELIVERY NETWORKS (IDNs) ARE THE TOP TARGET FOR INTERMEDIATE RISK MICROHEMATURIA

18

1.Management estimates derived from referred hematuria data in Woldu et al (2021). MH estimated at 80% and GH at 20%.

MH Risk categories: Low 7%, Intermediate 41%, High 52%. See slides 44-46 for details.

1

684k

456k

US COMMERCIAL PAYERS: MEDICARE POLICY EXPECTED TO UNLOCK VOLUMES
THE US PRIVATE HEALTH INSURANCE MARKET IS A LARGE OPPORTUNITY

•Commercial payers cover almost four times more lives than Medicare

•IRMH patients skew younger, female and commercially insured

•Final coverage policy from Medicare is expected to unlock revenue from

Commercial Payers by:

•Removing a key reason to deny reimbursement

•Providing additional evidence to overturn denials on appeal

•Providing language that commercial payers can adopt in their own

policies

•Leveraging State Biomarker Laws to mandate payment from

commercial payers

•We focus on establishing medical policy directly with payers or through

third parties like Avalon, EviCore, Carelon, Concert Genetics and ECRI

4

1.https://www.census.gov/library/publications/2025/demo/p60-288.html

2.https://www.medicare.gov/about-us

3.https://content.naic.org/sites/default/files/2024-annual-health-industry-commentary.pdf

4.ECRI is the Emergency Care Research Institute

~1,200

US private health

insurance payers

3

66m

Medicare

insured lives

2


223m

US private

insured lives

1


19

PACIFIC EDGE PAYER MIX (2H 26)

60%

20%

16%

2%

2%

COMMERCIAL

MEDICARE

MEDICARE

ADVANTAGE

VETERANS AFFAIRS

MEDICAID AND

MANAGED MEDICAID

APAC CHARTING A PATH TO PROFITABILITY
APAC – SMALL BUT SIGNFICANT

•APAC contributed 19% of operating revenue in

2H 26 with $2.0m in FY26

•APAC cash burn rate

2

of $0.17m in Q1 FY27,

•Repricing in 2025 created on average 25%

more revenue per test

•Triage Plus increased to 8% of product mix in

Q1 27

•Triage Plus has the potential for ~20%

more revenue per test

•APAC proves the ROW concept that can be

replicated in the Middle East, UK and Europe

pending IVD development

20

1.Total Laboratory Throughput in Asia and Pacific including commercial, pre-commercial and clinical studies testing

2.APAC Commercial and Clinical Operations cash burn figure is calculated on a director cost basis and excludes R&D costs

APAC TOTAL TEST VOLUME

1

AND COMMERCIAL PRODUCT MIX

75%

53%

45%

44%

41%

37.8%

15%

34%

43%

43%

46%

41.8%

0%

0%

0%

2%

1%

7.6%

10%

13%

12%

11%

12%

12.8%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Q4 25Q1 26Q2 26Q3 26Q4 26Q1 27

PRODUCT MIX (%)

TriageDetectTriage PlusMonitor

967

1,014

971

1,001

1,026

1,158

120

154

339

409

492

123

1,087

1,168

1,310

1,410

1,518

1,281

-

200

400

600

800

1,000

1,200

1,400

1,600

Q4 25Q1 26Q2 26Q3 26Q4 26Q1 27

TEST VOLUME

Clinical and non-commercial tests Commercial Volume

21
NEXT GENERATION PRODUCTS ALREADY DELIVERING STRATEGIC VALUE

TRIAGE PLUS AND SURVEILLANCE PLUS OFFER SUPERIOR PERFORMANCE, PRICING AND MARGIN

ADVANCING IVD DEVELOPMENT FOR INTERNATIONAL MARKETS

•Triage Plus and Surveillance Plus will be offered as CAP/CLIA-

approved LDTs

1

providing service to the entire USA

•International markets require a different approach in which Pacific

Edge seeks to create a ‘kitted’ IVD medical device

•Pacific Edge is simplifying its tests to create Triage Plus IVD for

decentralized lab deployment and international market expansion.

•Key objectives:

•Establishing IVD regulatory framework for our next

generation tests that includes IVD-R (Europe), FDA (USA) and

ISO-13485

2

(International)

•Prototype development plan is in place and ready to be

implemented subject to budget approval

1.CAP is the College of American Pathologists, CLIA is the Clinical Laboratory Improvement Amendments and LDT is a laboratory developed test

2.IVD-R European In Vitro Diagnostic Regulation; FDA, US Food and Drug Administration; ISO International Organization for Standardization

OUTLOOK
22

OUTLOOK
POSITIONED TO UNLOCK VALUE THROUGH UPCOMING COMMERCIAL, CLINICAL AND INNOVATION MILESTONES

LONG-TERM VALUE CREATION

RESEARCH INNOVATION

MEDIUM-TERM VALUE CREATION

CLINICAL EVIDENCE GENERATION

NEAR-TERM VALUE CREATION

COMMERCIAL CATALYSTS

•Case-by-case reimbursement for Triage

and Triage Plus under draft LCD

•Final LCD published by end of 2026

•US customers adopt Triage Plus at

US$1,328/test

•Building US Commercial payer medical

policy momentum

•Health New Zealand National Pathway

for Cxbladder

•Evidence generation program delivers

sustained strategic value

•US commercial payer policy for Triage

and Triage Plus drives test adoption

•AUA guideline review (2027/28)

expected to expand serviceable market

•Investigator initiated trials (IITs) generate

novel evidence for new indications

•Triage Plus and Surveillance Plus deliver

better patient outcomes at higher

margin pricing for improved unit

economics

•Targeting SurveillancePlus CPT-PLA

coding submission in June 2027 and

claim-by-claim revenue after 1 Jan 2028

•Seeking US$1,800 CMS pricing for

Surveillance Plus in FY28

•Product simplification and kitted IVD

products enable de-centralized

deployment in international markets

23

24
SIMON FLOOD

Chairman

QUESTIONS
25

RESOLUTIONS
26

VOTING
27

RESOLUTION 1: AUDITORS’ REMUNERATION
28

“To authorise the Directors to fix the auditors’ remuneration for the ensuing year.”

RESOLUTION 2: BRYAN WILLIAMS RE-ELECTION
29

“That Bryan Williams, who retires in accordance with NZX Listing Rule 2.7.1 and is

eligible for re-election, be re-elected as a Director of the Company.”

RESOLUTION 3: SIMON FLOOD ELECTION
30

“That Simon Flood, who retires in accordance with NZX Listing Rule 2.7.1 and is

eligible for election, be elected as a Director of the Company.”

RESOLUTION 4: PAYMENT TO SIMON FLOOD
31

“That the payment in cash of $12,699 to Simon Flood, being unpaid Director

remuneration that has accrued to him in respect of the period from 19 December

2025 to 31 March 2026, as described in the Explanatory Notes, be approved for all

purposes, including NZX Listing Rule 2.11.1.”

RESOLUTION 5: APPROVAL OF SHARE ISSUE
32

“That the issue of 152,561,001 Shares under NZX Listing Rule 4.5.1, being Shares

issued under the Placement, Shares issued to certain participants in the Retail Offer,

and Shares issued in consideration for professional services provided in connection

with the Placement and Retail Offer, be approved and ratified for all purposes,

including NZX Listing Rule 4.5.1(c)

RESOLUTION 6: ISSUE OF SHARES TO CERTAIN PARTICIPANTS
33

“That the issue of 59,998,716 Shares under NZX Listing Rule 4.3.1(c), being Shares

issued to certain participants in the Retail Offer, be approved and ratified for all

purposes, including paragraph (a) of the definition of “share purchase plan” in the NZX

Listing Rules.”

PROXY VOTING DIRECTIONS
34

RESOLUTION FOR

*

OPEN

*

AGAINST

*

TOTAL

**

1. Auditors’ remuneration 571,843,459 (97.4%)14,836,084 (2.5%)406,612 (0.7%)587,086,155 (47.3%)

2. Re-election of Bryan Williams 570,426,875 (97.1%)14,839,284 (2.5%)2,067,893 (0.4%)587,334,052 (47.3%)

3. Election of Simon Flood571,784,791 (97.4%)14,839,284 (2.5%)657,390 (0.1%)587,281,465 (47.3%)

4. Payment to Simon Flood571,026,067 (98.1%)10,250,528 (1.8%)1,072,708 (0.2%)582,349,303 (46.9%)

5. Approval of share issue 383,502,592 (97.3%)10,250,528 (2.6%)448,731 (0.1%)394,201,851 (31.7%)

6. Issue of shares to certain

participants

521,723,100 (97.1%)14,835,739 (2.8%)945,324 (0.2%)537,504,163 (43.3%)

*Percentage figures in the ‘For’, ‘Open’ and ‘Against’ columns indicate proportion of total votes notified (excludes abstentions)

** Percentage figures in the ‘Total’ column indicate total votes notified (excludes abstentions) against issued capital.

GENERAL BUSINESS
35

MEETING CLOSE
36

APPENDIX
37

BLADDER CANCER – A SIGNIFICANT GLOBAL HEALTHCARE CHALLENGE
AN INVASIVE STATUS QUO – A NON-INVASIVE OPPORTUNITY

38

1.Sievert et al (2009) Economic aspects of bladder cancer: what are the benefits and costs? World J Urol. 2009 Mar 7;27(3):295–300. doi: 10.1007/s00345-009-0395-z

2.World Cancer Research Fund. Statistics are from 2022.

3.Average recurrence for low grade non-muscle invasive bladder cancer as published in Palou J et al (2012): Eur Urol 2012; 62: 118.

4.The Survey was conducted by the Bladder Cancer Advocacy Network (BCAN)

5.Company estimate

1

st


Costliest cancer to

treat on a per-

patient basis

1

6

th

Most common

cancer in men

2

9

th

Most common

cancer world-wide

2

~614K

Annual cases

and growing

2

>220K

Annual

Deaths

2

>50%

Recurrence

3

4.9m

5

Annual cystoscopies avoided globally if Cxbladder tests were used to

evaluate intermediate risk patients presenting with hematuria

5


CYSTOSCOPY CXBLADDER TEST

•Cystoscopy – an invasive, uncomfortable and costly procedure to visually

inspect the bladder by inserting a camera into the urethra

•The standard hematuria workup, where the majority of patients are

found to have no cancer

•In a survey

4

of US NMIBC patients under surveillance, 78% said they

experienced some pain, with 25% saying it was moderate to “worst

imaginable”

•The result is systemic over-proceduralization: millions of avoidable

cystoscopies every year, adding cost, patient discomfort, infection risk and

urology backlog

•Non-invasive genomic urine testing like Cxbladder can rule out cancer and

prioritize patients who truly need cystoscopy – a large unmet clinical need

•Women are an under-served market, with hematuria frequently

dismissed as urinary tract infections (UTI)

Source: Nursing Skills

CXBLADDER: TESTS TO RULE OUT CANCER OR PRIORITIZE PATIENTS
THE PATIENT CARE PATHWAY

1.RDM: Residual Disease Monitoring

2.TRM: Therapeutic Response Monitoring

3.NMIBC: non-muscle invasive bladder cancer

4.AUA: American Urological Association

5.AV, CV, CU are Analytical Validity, Clinical Validity, and Clinical Utility which are required for medical policy and guidelines

>130,000

Patients that have used

Cxbladder

>5,000

Urologists that have ordered

Cxbladder

>30

Publications demonstrating AV,

CV or CU evidence

5


Grade A

Evidence rating by the AUA

4

in its

2025 Microhematuria Guideline

•Cxbladder avoids invasive, unnecessary procedures saving >US$500/patient driving down costs for health systems and payers
2

•Only 63% of counties in the US have a registered urologist

3

and only 13% of high-risk microhematuria patients receiving a cystoscopy

4


•The US population is ageing and the urologists per person over 65 is falling (from 23.8/100k to 15.8/100k in 2035

5

) potentially delaying diagnosis

•Medicare reimbursement for cystoscopy has declined from US$204.80 in 2023 to US$172.80 in 2026

6

1.AUA Guidelines cite incidence of bladder cancer in microhematuria risk categories from 0.4-6%. 5% is an example

2.Tyson et al (2024) Budgetary Impact of Including the Urinary Genomic Marker Cxbladder Detect in the Evaluation of Microhematuria Patients - PubMed (PMID: 37914255)

3.https://www.auanet.org/research-and-data/aua-census/census-results

4.https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.25048

5.Nam et al. (2021) Projected US Urology Workforce per Capita, 2020-2060 JAMA Network Open Published Online:November16,2021

6.https://www.cms.gov/medicare/physician-fee-schedule/search

DRIVING ECONOMIC VALUE FOR PATIENTS, HOSPITALS AND PAYERS

CXBLADDER DELIVERS CLINICAL UTILITY, PATIENT SATISFACTION AND ECONOMIC VALUE

Illustration shows incidence of bladder cancer in microhematuria

populations at 5%

1

With Triage Plus, 85% of patients can avoid cystoscopy, 15% receive

cystoscopy to find the same 5 cancer patients

40

CANCER INCIDENCE IN MICROHEMATURIA PATIENTSCYSTOSCOPIES SAFELY AVOIDED USING CXBLADDER

Cystoscopy

No cancer

Cystoscopy

Cancer

No cystoscopy

No cancer

Cystoscopy

Cancer

Cystoscopy

No cancer

Calendar year
Pre

2023

202320242025202620272028

Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2

STRATA

DRIVE

AUSSIE

microDRIVE

Pooled CV

CREDIBLE

HEMATURIA EVALUATION FIVE YEAR CLINICAL STUDIES ROADMAP

*

*

*

*

*

Publication Submitted

Records review / follow-up

Database lock

Legend:

Pre-activation (docs, CTA etc)

SIV

Enrollment

Data Cleaning

*

DBL

DBL

DBL

41

Calendar year
Pre

2023

202320242025202620272028

Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2Q3Q4Q1Q2

“The 1800”

1

LOBSTER

OCTOPUS

*

SURVEILLANCE FIVE YEAR CLINICAL STUDIES ROADMAP

42

Publication Submitted

Records review / follow-up

Database lock

Legend:

Business case approved

SIV

Enrollment

Data Cleaning

*

DBL

Scheduled surveillance visits

CAB

2

1.“The 1800” is the Surveillance Plus development dataset

2.CAB is the Pacific Edge Clinical Advisory Board. It was convened at SUO in Arizona to review and confirm the clinical study trial design for OCTOPUS

THE CXBLADDER SUITE
Hematuria EvaluationNMIBC

1

Surveillance

Cxbladder Product

TriageDetectTriage PlusMonitorSurveillance Plus

Product Summary

Risk stratification of

microhematuria patients to

rule out the majority of those

patients from further workup

for bladder cancer

Adjunctive use with

cystoscopy on hematuria

patients to resolve diagnostic

dilemmas (e.g. equivocal

cystoscopy and atypical

cytology)

Risk stratification and

adjunctive use on any

hematuria patient with

improved performance over

Triage and Detect

Alternative to cystoscopy

for NMIBC patients

undergoing surveillance

for recurrence

Alternative to cystoscopy for

NMIBC patients undergoing

surveillance for recurrence.

Currently in development,

showing improved

performance

Analytical composition

5 RNA biomarkers + patient clinical

factors

5 RNA biomarkers

5 RNA biomarkers + 6 DNA

SNVs from 2 genes (FGFR3/

TERT)

5 RNA biomarkers + patient

tumor history

13 SNVs across 5 genes

2 fusions associated with 1 gene

1 methylation marker

2 control markers

Test Performance

Hematuria

2

Sn: 95%

Sp: 45%

NPV: 99%

PPV: N/A

Hematuria

3

Sn: 82%**

Sp: 94%*

NPV: 97%**

PPV: 68%*

Hematuria

4

Sn: 93.6%****

Sp: 98.2%***

NPV: 99.4%****

PPV: 74.6%***

All risk groups

5,6

Sn: 93%

Sp: N/A

NPV: 97%

PPV: N/A

All Risk Groups

Sn: Not yet published

Sp: Not yet published

NPV: Not yet published

PPV: Not yet published

When is it used?

Prior to cystoscopyPrior to cystoscopy / as an adjunct / 3 weeks post cystoscopyAs a non-invasive surveillance alternative

Commercially

available?



Commercially available in APAC

and under “early access” in US,

pending coverage


CPT-PLA code targeted for Dec 2026

Reimbursed on A58917 in Jul 2027

Medicare Pricing (USD)

$760$760

$1,328$760$1,800 (seeking by crosswalk)

1.NMIBC: non-muscle invasive bladder cancer

2.Kavalieris et al. (2015) A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low

probability of urothelial carcinoma. BMC Urol 2015;15:23.

3.O’Sullivan et al. (2012) A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria. J Urol 2012; 188:741–7.

4.Harvey et al. (2025) Analytical Validation of the Cxbladder® Triage Plus Assay for Risk Stratification of Hematuria Patients for Urothelial Carcinoma. Diagnostics. 2025; 15(14):1739. https://doi.org/10.3390/diagnostics15141739

5.Kavalieris et al. (2017) Performance Characteristics of a Multigene Urine Biomarker Test for Monitoring for Recurrent Urothelial Carcinoma in a Multicenter Study. J Urol 2017;197:6,1419-1426.

6.Lotan et al. (2017) Clinical comparison of noninvasive urine tests for ruling out recurrent urothelial carcinoma. Urologic Oncology: Seminars and Original Investigations. Elsevier; 2017; 1–8.

* When higher 0.23 cut point on test report is used

** When lower 0.12 cut point on test report is used

*** When higher 0.54 cut point on test report is used

**** When lower 0.15 cut point on test report is used

43

SOURCES AND ASSUMPTIONS - TOTAL ADDRESSABLE MARKET (US)
44

REGIONSTATISTICSOURCE

UNITED STATES

Population 341,762,685https://www.census.gov/popclock/

Incidence of hematuria7,000,000

Presentation from Dr Sia Daneshmand (Director of

Urologic Oncology and Clinical Research, USC) July 2019

Referred for clinical workup3,500,000

Presentation from Dr Sia Daneshmand (Director of

Urologic Oncology and Clinical Research, USC) July 2019

Proportion of gross hematuria amongst

those referred for clinical workup700,000Pacific Edge estimate

Proportion of microhematuria amongst

those referred for clinical workup2,800,000Pacific Edge estimate

Proportion of low-risk microhematuria 200,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

Pacific Edge estimates to account for AUA 2025

guidelines

Proportion of intermediate-risk

microhematuria 1,140,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

Pacific Edge estimates to account for AUA 2025

guidelines

Proportion of high-risk microhematuria 1,460,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

Pacific Edge estimates to account for AUA 2025

guidelines

Annual cases of bladder cancer 84,870

National Cancer Institute

Patients living with bladder cancer 744,044

National Cancer Institute

Test opportunities 4,416,066Pacific Edge estimate

Price of Cxbladder (US$)

$1,328 for Cxbladder Triage Plus, $1,800 for Cxbladder

Monitor

TAM (US$billion)$6.4

SOURCES AND ASSUMPTIONS - TOTAL ADDRESSABLE MARKET (EUROPE)
45

REGIONSTATISTICSOURCE

EUROPE (EXCLUDING

RUSSIA)

Population

600,000,000World-population - Europe

World-population - Russia

Incidence of hematuria12,000,000

Science Direct

Referred for clinical workup6,000,000

Presentation from Dr Sia Daneshmand (Director of

Urologic Oncology and Clinical Research, USC) July 2019

Proportion of gross hematuria amongst

those referred for clinical workup1,200,000Pacific Edge estimate

Proportion of microhematuria amongst

those referred for clinical workup4,800,000Pacific Edge estimate

Proportion of low-risk microhematuria 340,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

Pacific Edge estimates to account for AUA 2025

guidelines

Proportion of intermediate-risk

microhematuria 1,960,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

Pacific Edge estimates to account for AUA 2025

guidelines

Proportion of high-risk microhematuria 2,500,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

Pacific Edge estimates to account for AUA 2025

guidelines

Annual cases of bladder cancer 180,000

Uroweb

Patients living with bladder cancer 900,000Pacific Edge estimate - 5 years of annual cases

Test opportunities 7,010,000Pacific Edge estimate

Price of Cxbladder EURO€245Pacific Edge estimate

TAM (US$billion)$1.9

SOURCES AND ASSUMPTIONS - TOTAL ADDRESSABLE MARKET (APAC)
46

REGIONSTATISTICSOURCE

APAC (EXCLUDING INDIA

AND CHINA)

Population

830,000,000

World population - Southeast Asia

Population Pyramid - Japan

Population Pyramid - Hong Kong

Incidence of hematuria16,600,000

Science Direct

Referred for clinical workup

8,300,000

Presentation from Dr Sia Daneshmand (Director of

Urologic Oncology and Clinical Research, USC) July 2019

Proportion of gross hematuria amongst

those referred for clinical workup

1,660,000

Pacific Edge estimate

Proportion of microhematuria amongst

those referred for clinical workup

6,640,000

Pacific Edge estimate

Proportion of low-risk microhematuria

470,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

AUA 2025 guidelines

Proportion of intermediate-risk

microhematuria

2,710,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

AUA 2025 guidelines

Proportion of high-risk microhematuria

3,460,000

Woldu, S, et al. Evaluation of the New American Urological

Association Guidelines Risk Classification for Hematuria;

AUA 2025 guidelines

Annual cases of bladder cancer

58,000

WHO

Hong Kong

Patients living with bladder cancer 290,000Pacific Edge estimate - 5 years of annual cases

Test opportunities 3,531,000Pacific Edge estimate

Price of Cxbladder (US$)$550Pacific Edge estimate

TAM (US$billion)$1.9

FOR MORE INFORMATION:
Dr. Peter Meintjes

Chief Executive Officer

email: peter.meintjes@pelnz.com

Grant Gibson

Chief Financial Officer

email: grant.gibson@pelnz.com

Pacific Edge

87 St David Street, PO Box 56, Dunedin, New Zealand

P +64 3 577 6733 Within NZ 0800 555 563

email: investors@pacificedge.co.nz

www.pacificedgedx.com

47

---

PACIFIC EDGE 2026 ANNUAL SHAREHOLDERS’ MEETING
CHAIRMAN’S ADDRESS

Welcome everyone to Pacific Edge’s 2026 Annual Shareholders’ Meeting. My name is Simon

Flood, and I’m a Director and Chair of Pacific Edge.

This is my first Annual Shareholders’ Meeting having been appointed to the Board in December

last year and assumed the role of Chair following Chris Gallaher’s retirement.

I am very pleased to welcome shareholders joining us here in Auckland and those participating

online.

I would like to spend a few moments putting Pacific Edge’s current position in context — where

we’ve been, the opportunity we have in front of us, why we’re positive about the future, and to

clearly set out what we believe we need to do to realize the opportunities we see.

When I joined Pacific Edge late last year, I did so because I believed the company had

assembled something rare and tremendously exciting in a sector that I have a strong affinity

with: patented, non-invasive tests with proven clinical utility, a substantial and expanding

evidence base, a recognised patient and healthcare system need, and a meaningful global

opportunity.

I also believed that the Medicare process, while challenging, would ultimately recognize the

value Cxbladder offers.

That conviction has strengthened.

The draft Local Coverage Determination (LCD) published by Medicare Administrative Contractor

Novitas in May proposes Medicare coverage for both Cxbladder Triage and Cxbladder Triage

Plus — our tests for the evaluation of patients presenting with hematuria, blood in urine.

Importantly, those are the only biomarkers proposed to be reimbursable under that policy.

This is a company-defining milestone and a significant validation of our evidence-led strategy

and is major step forward to an opportunity worth — in revenue terms — US$10.2 billion

annually.

Our work is incomplete in this regard, but the draft LCD is a huge step forward and a hard-won

recognition for the years of work put in by our Team lead by Pete Meintjes. The LCD remains

draft, and disciplined execution remains essential as we await confirmation of a final LCD which

we hope to receive before the end of this year. The difference that the draft LCD makes is that

it gives Pacific Edge a clearer reimbursement pathway and a legitimacy that confirms Cxbladder

as the leader in its field, and that’s a great place for us to start rebuilding sales momentum.

Bladder cancer diagnosis often begins with the evaluation of the causes of hematuria and there

are millions of hematuria evaluations each year in the United States.

Cxbladder is designed to help identify hematuria patients at a low risk of cancer. Appropriately

used, it will ensure that patients are able to receive an accurate diagnosis, that was previously

only available if they underwent a cystoscopy, a procedure many have chosen to avoid given its

invasive nature.

The risk stratification of patients by clinicians also ensures that higher-risk patients continue

through the appropriate pathway which has been freed up by the redirection of those low and

2

intermediate risk patients. That delineation of care is valuable for patients, clinicians, and the

healthcare system as a whole.

Pacific Edge is now better positioned to pursue that opportunity than it was twelve months ago.

The draft LCD deepens the commercial and scientific moat around the business. The inclusion

of Triage Plus also opens the potential for improved unit economics.

Growing commercial payer support in the United States from what effectively amounts to a

validation of our products will in turn support growth in other markets such as the Asia Pacific

where we are seeing steady progress.

This next slide puts the current moment in context.

Pacific Edge’s progress has been the result of a long and deliberate journey: building evidence,

establishing diagnostic operations in New Zealand and the United States, launching Cxbladder

products, securing early commercial use, and working over many years to embed our tests into

clinical practice.

For a diagnostics company, adoption is earned through evidence, demonstrated clinical utility,

better patient pathways, and the confidence of clinicians and payers. Pacific Edge has done that

hard work.

The achievements of the last two years have been significant markers on that journey. They

include:

- the groundbreaking STRATA study that established the clinical utility of Cxbladder Triage;

- the inclusion of that test in the American Urological Association Guideline in 2025;

- the resounding support for the test expressed by the expert Contractor Advisory

Committee convened by Novitas in February of this year; and

- now the draft LCD.

Together they have endorsed our strategy of placing thoroughly researched and validated

clinical evidence at the heart of value creation. Those elements also give us a highly credible

pathway to convert market access into growth and, over time, profitability.

As shareholders will be well aware this journey has not been linear. The Medicare non-coverage

period was a serious challenge.

But the long-term direction of travel is clear: the company has continued to build evidence,

protect its intellectual property and develop products with the potential to improve the standard

of care in bladder cancer diagnostics.

That is also the basis for my own conviction.

I am aligned with shareholders not only as Chair, but as someone who has chosen to invest

personally in Pacific Edge. I have done so alongside my fellow directors, management and the

broader team because we believe the opportunity is real, the evidence is increasingly

recognized, and the company now has a pathway to create substantially greater value if it

executes well.

Turning now to FY26.

The financial results reflect the impact of Medicare non-coverage. Commercial test volumes and

operating revenue were down, and the company recorded a large net loss. Those have been

real challenges.

3

Still, as I have highlighted FY26 was a year of strategic delivery. Pacific Edge preserved the core

assets required to scale, managed costs carefully, reduced cash burn in the second half, and

completed a capital raising to support the next phase of the strategy, which is all about delivery

and growth.

Most importantly, FY26 delivered the draft LCD. The company also built commercial payer

momentum in the United States, while Asia Pacific continued to advance through clinical

pathway adoption and commercial progress.

These developments broaden the opportunity beyond Medicare alone.

Triage Plus also improves the outlook. Its higher performance and Medicare price create the

potential to improve revenue per reimbursed test, margins and the company’s path to

profitability. Surveillance Plus remains an important future opportunity, with further clinical

validation and reimbursement steps ahead.

Pacific Edge is in a materially stronger strategic position than it was a year ago.

The message I want to leave shareholders with is this: Pacific Edge has been through a difficult

period, but it has not stood still. It has protected and strengthened the foundations of the

business.

As Chair, I am excited about the future of Pacific Edge.

I am also realistic about the execution required. We will continue to be measured, disciplined

and transparent and I believe the company now can convert its first-mover position, clinical

evidence, and product innovation into meaningful value for patients, healthcare systems, and

shareholders.

On behalf of the Board, I thank our shareholders for your patience and support, the Pacific Edge

team for their commitment, and the clinical community whose engagement has helped to bring

the company to this important point.

I will now hand over to Peter, who will speak in more detail about the company’s operational

progress, commercial priorities, and outlook.

/end

Data sourced from publicly available filings. Our datasets may not be complete. Automated analysis can produce errors. If you believe any data on this page is incorrect, please contact us at hello@nzxplorer.co.nz. For informational purposes only. Not investment advice.